Reader in Cell and Molecular Biology in Biology, University of East Anglia (2009-current)
Senior Lecturer in Cell and Molecular Biology in Biology, University of East Anglia (2007-2009)
Lecturer in Cell and Molecular Biology in Biology, University of East Anglia (2002-2007)
Postdoctoral researcher, The Sainsbury Laboratory, Norwich, UK (1997-2002)
EMBO Fellow, The Sainsbury Laboratory, Norwich, UK (1995-1997)
Ph.D. - Agricultural Biotechnology Centre, Godollo, Hungary (1995)
B.Sc. - Genetics, University of Budapest, Hungary (1990)

Key Research Interests

I am a molecular biologist with primary interests in RNA silencing. Our research uses both plant and animal systems (Arabidopsis, tomato, mammals, chicken, etc.). The major theme in our laboratory is the role of microRNAs in various biological processes. 

Current Research Projects

The role of short RNAs in tomato fruit development
Investigating the role of microRNAs in cartilage development
Biological function of miR-449, a choroid plexus specific microRNA
Analysis the role of short RNAs in dehydration stress tolerance using plant model systems




 

Life in our research group

We use molecular techniques to study short RNAs that regulate the expression of protein coding genes. Our research involves a variety of species including both plants and animals. Our group is very international and a good mixture of students and postdocs. The weekly lab meetings are shared with a bioinformatics group at the School of Computing Sciences (Moulton group) because most projects involve a strong bioinformatics component. The laboratory is well funded and even owns a Wii console.

PhD Positions

Click here for current PhD opportunities in BIO. But feel free to email me to discuss projects outside these areas and alternative sources of funding.

Postdocs & Fellows

There are no positions currently but feel free to approach me to discuss possibilities (e.g. fellowships from EMBO or EU).

Research Group

Sara Lopez-Gomollon Postdoctoral fellow funded by the Spanish Government (2009-2010) Studying the role of short RNAs in tomato fruit development

Karim Sorefan BBSRC funded Postdoctoral research associate (2009-2012) Studying the role of short RNAs in tomato fruit development

Adam Hall BBSRC funded PhD student (2009-2012) Biological function of miR-449, a choroid plexus specific microRNA

Hannah Tudor BBSRC and KWS CASE PhD student (2007-2010) ‘Short RNAs in sugar beet’

Siqi Huang Visiting PhD student funded by the Chinese Government (2090-2010) microRNAs in abiotic stress

Carly Turnbull BBSRC PhD student (2009-). Short RNAs during virus infection.

Gyorgy Szittya BBSRC funded ERA-NET Postdoctoral research associate (2009-2012) ‘Analysis the role of short RNAs in poplar tree’

Francisco Nicolas-Molina EU (FP6) funded Postdoctoral research associate (2007-2010) Investigating the role of microRNAs in regulation of gene expression in mammalian cells

External & Professional Activities

Grant reviewer for BBSRC, MRC, Wellcome Trust and foreign funding bodies (e.g. DFG (German), Irish Health Research Board, Horizon and NOW (Dutch), Medical Science Foundation Innsbruck, Austria)
Invited speaker to meetings in the UK, Sweden, Germany, Denmark, Italy, etc.
Sub-project organiser in an FP6 consortium SIROCCO ‘Silencing RNAs:organisers and coordinators of complexity in eukaryotic organisms’
Handling Editor for FEBS Letters
Co-Editor for Journal of Integrated Plant Biology (JIPB)

Internal Administration & Teaching Activities

I am Director of Research in the School of Biological Sciences (2008-)
Member of the BIO Executive, Teaching Executive and Promotion Committee
I give lectures on Plant Biology (2B07, 3C06 and M629), Molecular Biology (2B02) and Gene silencing/RNA interference (3C39 and 3C41). I also teach in small group seminars: Skills for Biologists (1A4Y), Seminars in Cell Biology (2B06) and Introduction to Biomedicine (1A5Y), and in practicals (1A14 and 2B16).

Recent Publications (2001-present)

Kawashima, C.G., Yoshimoto, N., Maruyama-Nakashita, A., Tsuchiya, Y., Saito, K., Takahashi, H. & Dalmay, T., 2009,  Sulphur starvation induces the expression of microRNA-395 and one of its target genes but in different cell types,Plant Journal, 57(2), 313-321,  Full Text (subscription) Request Publication

Redshaw, N., Wheeler, G., Hajihosseini, M.K. & Dalmay, T., 2009,  microRNA-449 is a putative regulator of choroid plexus development and function,Brain Research, 1250, 20-26,  Full Text (subscription) Request Publication

Lewis, M., Quint, E., Glazier, A.M., Fuchs, H., De Angelis, M.H., Langford, C., Van Dongen, S., Abreu-Goodger, C., Piipari, M., Redshaw, N., Dalmay, T., Moreno Pelayo, M.A., Enright, A. & Steel, K.P., 2009,  An ENU-induced mutation of a miRNA associated with progressive hearing loss,Nature Genetics, 41(5), 614-618,  Full Text (subscription) Request Publication

Johnston, I.A., Lee, H.T., Macqueen, D.J., Paranthaman, K., Kawashima, C., Anwar, A., Kinghorn, J.R. & Dalmay, T., 2009,  Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genomewide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes,The Journal of Experimental Biology, 212, 1781-1793,  Full Text (subscription) Request Publication

Rathjen, T., Pais, H., Sweetman, D., Moulton, V., Munsterberg, A. & Dalmay, T., 2009,  High throughput sequencing of microRNAs in chicken somites,FEBS Letters, 583(9), 1422-1426,  Full Text (subscription) Request Publication

Mencia, A., Modamio-Hoybjor, S., Redshaw, N., Morin, M., Mayo-Merino, F., Olavarrieta, L., Aguirre, L.A., del Castillo, I., Steel, K.P., Dalmay, T., Moreno, F. & Moreno-Pelayo, M.A., 2009,  Mutations in the seed region of the human miR-96 are responsible for non-syndromic progressive hearing loss,Nature Genetics, 41(5), 609-613,  Full Text (subscription) Request Publication

Dalmay, T., 2008,  MicroRNAs and cancer,Journal of Internal Medicine, 263, 366-375,  Full Text (subscription) Request Publication

Ho, T.X., Rusholme, R., Dalmay, T. & Wang, H., 2008,  Cloning of short interfering RNAs from virus-infected plants,Methods in Molecular Biology, 451, 229-241,  Full Text (subscription) Request Publication

Sweetman, D., Goljanek, K., Rathjen, T., Oustanina, S., Braun, T., Dalmay, T. & Munsterberg, A., 2008,  Regulation of muscle specific microRNAs, miR-1/206 and miR-133, demonstrates differential activities of MRFs in vivo,Developmental Biology, 321(2), 491-499,  Full Text (subscription) Request Publication

Ho, T., Rusholme, R., Edwards, M-L., Cooper, I., Dalmay, T. & Wang, H., 2008,  Evidence for GC preference by monocot Dicer-like proteins,Biochemical and Biophysical Research Communications, 368(2), 433-437,  Full Text (subscription) Request Publication

Moxon, S., Jing, R., Szittya, G., Schwach, F., Rusholme Pilcher, R.L., Moulton, V. & Dalmay, T., 2008,  Deep sequencing of tomato short RNAs identifies microRNAs targeting genes involved in fruit ripening,Genome Research, 18(10), 1602-1609,  Full Text (subscription) Request Publication

Moxon, S., Schwach, F., Maclean, D., Dalmay, T., Studholme, D.J. & Moulton, V., 2008,  A toolkit for analysing large-scale plant small RNA datasets,Bioinformatics, 24(19), 2252-2253,  Full Text (subscription) Request Publication

Nicolas, F.E., Pais, H., Schwach, F., Lindow, M., Kauppinen, S., Moulton, V. & Dalmay, T., 2008,  Experimental identification of microRNA-140 targets by silencing and over-expressing miR-140,RNA, 14, 2513-2520,  Full Text (subscription) Request Publication

Dalmay, T., 2008,  Identification of genes targeted by microRNAs,Biochemical Society Transactions, 36, 1194-1196,  Full Text (subscription) Request Publication

Szittya, G., Moxon, S., Santos, D.M., Jing, R., Fevereiro, M.P., Moulton, V. & Dalmay, T., 2008,  High-throughput sequencing of Medicago truncatula short RNAs identifies eight new miRNA families,BMC Genomics, 9(1), 593,  Full Text (subscription) Request Publication

Herbandez-Pinzon, I., Yelina, N.E., Scwach, F., Studholme, D., Baulcombe, D. & Dalmay, T., 2007,  SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA.,Plant Journal, 50, 140-148,  Full Text (subscription) Request Publication

Wheeler, G., Valoczi, E., Havelda, Z. & Dalmay, T., 2007,  In situ detection of animal and plant miRNAs.,DNA and Cell Biology, 26, 251-255,  Full Text (subscription) Request Publication

Phillips, J., Dalmay, T. & Bartels, D., 2007,  The role of small RNAs in abiotic stress.,FEBS Letters, 581(19), 3592-3597,  Full Text (subscription) Request Publication

Pilcher, R.L., Moxon, S., Pakseresht, N., Moulton, V., Manning, K., Seymour, G. & Dalmay, T., 2007,  Identification of novel small RNAs in tomato (Solanum lycopersicum).,Planta, 226(3), 709-717,  Full Text (subscription) Request Publication

Ho, T., Wang, H., Pallett, D. & Dalmay, T., 2007,  Evidence for targeting common siRNA hotspots and GC preference by plant Dicer-like proteins,FEBS Lett, 581(17), 3267-3272,  Full Text (subscription) Request Publication

Csorba, T., Bovi, A., Dalmay, T. & Burgyan, J., 2007,  The p122 subunit of Tobacco mosaic virus replicase is a potent silencing suppressor and compromises both siRNA and miRNA mediated pathways,Journal of Virology, 81, 11768-11780,  Full Text (subscription) Request Publication

Wheeler, G., Ntonuia-Fousara, S., Granda, B., Rathjen, T. & Dalmay, T., 2006,  Identification of new central nervous system specific mouse microRNAs.,FEBS Letters, 580, 2195-2200,  Full Text (subscription) Request Publication

Dalmay, T., 2006,  Short RNAs in environmental adaptation.,Proceedings of the Royal Society of London B, 273, 1579-1585,  Full Text (subscription) Request Publication

Sweetman, D., Rathjen, T., Jefferson, M., Wheeler, G., Smith, T.G., Wheeler, G.N., Munsterberg, A. & Dalmay, T., 2006,  FGF-4 signalling is involved in mir-206 expression in developing somites of chicken embryos.,Developmental Dynamics, 235, 2185-2191,  Full Text (subscription) Request Publication

Tuddenham, L., Wheeler, G., Ntounia-Fousara, S., Waters, J., Hajihosseini, M.K., Clark, I. & Dalmay, T., 2006,  The cartilage specific microRNA-140 targets Histone Deacetylase 4 in mouse cells.,FEBS Letters, 580, 4214-4217,  Full Text (subscription) Request Publication

Ho, T., Pallett, D., Rusholme, R., Dalmay, T. & Wang, H., 2006,  A simplified method for cloning of short interfering RNAs from Brassica juncea infected with Turnip mosaic potyvirus and Turnip crinkle carmovirus.,Journal of Virological Methods, 136, 217-223,  Full Text (subscription) Request Publication

Rathjen, T., Hunton, C., McConkey, G. & Dalmay, T., 2006,  Analysis of short RNAs in the malaria parasite and its red blood cell host.,FEBS Letters, 580, 5185-5188,  Full Text (subscription) Request Publication

Dalmay, T. & Edwards, D.R., 2006,  MicroRNAs and the Hallmarks of Cancer.,Oncogene, 25, 6170-6175,  Full Text (subscription) Request Publication

Dalmay, T., 2005,  Virus Induced Gene Silencing.,Plant Epigenetics, , 223-237,  Full Text (subscription) Request Publication

Herr, A.J., Jensen, M.B., Dalmay, T. & Baulcombe, D.C., 2005,  RNA polymerase IV directs silencing of endogenous DNA.,Science, 308, 118-120,  Full Text (subscription) Request Publication

Szittya, G., Silhavy, D., Dalmay, T. & Burgyan, J., 2002,  Size-dependent cell-to-cell movement of defective interfering RNAs of Cymbidium ringspot virus.,Journal of General Virology, 83, 1505-1510,  Full Text (subscription) Request Publication

Dalmay, T., Horsefield, R., Braunstein, T.H. & Baulcombe, D., 2001,  SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis.,EMBO Journal, 20, 2069-2077,  Full Text (subscription) Request Publication